不对称催化合成(R)-2-羟基-4-苯基丁酸乙酯

Study on Enantioselective Hydrogenation to Synthesize Ethyl(R)-2-Hydroxy-4-Phenylbutyrate

用 Pt-Cinchona 生物碱体系催化加氢合成(R)-2-羟基-4-苯基丁酸乙酯。进行了催化剂的制备和比较研究,并考察了修饰剂用量、2-氧代-4-苯基丁酸乙酯的初始浓度、反应氢压和温度对转化率和(R)-2-羟基-4-苯基丁酸乙酯得率的影响,得到了适宜的反应条件,在此条件下产物中(R)-2-羟基-4-苯基丁酸乙酯得率可达70%以上。实验结果表明,本研究中不对称加氢速率与光学收率呈良好线性关系,对研究不对称合成反应的规律有一定的意义。

Enantioselective hydrogenation of Ethyl 2-oxo-4-phenylbutyrate to Ethyl (R)-2-hy-droxy-4-phenylbutyrate on cinchona-modified platinum catalysts was studied. The influences of HCd amount, initial EOPB concentration, hydrogen pressure and temperature on conversion and yield of Ethyl (R)-2-hydroxy-4-phenylbutyrate were investigated. Under the better reaction conditions, the yield of Ethyl (R)-2-hydroxy-4-phenylbutyrate can exceed 70%. The experimental results demonstrated that rates and enantiometric excesses showed good linear correlation in the reactions. The conclusions can be used for the reference to study the analogous reaction systems.