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X射线修复交叉互补基因功能的研究进展 被引量：4

The recent advance in identification and functions of X ray repair cross complementing genes
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摘要 对X射线修复交叉互补(XRCC)基因功能的研究极大地促进了对哺乳动物DNA损伤修复过程和遗传不稳定性致癌机制的理解。通过观察XRCC基因突变体的表型,可以对其功能进行鉴定。目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。XRCC基因的鉴定及其在DNA损伤修复和维持遗传稳定性过程中发挥重要的作用。 The researches on functions of X ray repair cross complementing(XRCC) genes had promoted the understanding of DNA damage repair processes and the mechanism of cancer induced by genetic instability. The functions of XRCC genes could be identified by studying their mutant phenotypes. Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining. The identification of XRCC genes and their functions took important parts in DNA damage repairs and genetic stability processes.
作者 王芹
机构地区 中国医学科学院协和医科大学放射医学研究所
出处 《国外医学（放射医学核医学分册）》 2005年第3期132-136,共5页 Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词 X射线修复交叉互补基因 碱基切除修复 同源重组修复 非同源末端重接 X ray repair cross complementing genes base excision repair homologous recombination repair non-homologous end joining
分类号 Q345.7 [生物学—遗传学]
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参考文献14

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同被引文献32

  • 1Demuth I,Digweed M. T The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome[J].Oncogene,2007,(56):7792-7798.doi:10.1038/sj.onc.1210876.
  • 2Yano K,Morotomi-Yano K,Adachi N. Molecular mechanism of protein assembly on DNA double-strand breaks in the non-homologous end-joining pathway[J].Journal of Radiation Research,2009,(02):97-108.doi:10.1269/jrr.08119.
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  • 4Roberts SA,Ramsden DA. Loading of the nonhomologous end joining factor,Ku,on protein-occluded DNA ends[J].Journal of Biological Chemistry,2007,(14):10605-10613.
  • 5Mari PO,Florea BI,Persengiev SP. Dynamic assembly of endjoining complexes requires interaction between Ku70/80 and XR-CC4[J].Proceedings of the National Academy of Sciences(USA),2006,(49):18597-18602.doi:10.1073/pnas.0609061103.
  • 6Evans JW,Liu XF,Kirchgessner CU. Induction and repair of chromosome aberrations in scid cells measured by premature chromosome condensation[J].Radiation Research,1996,(01):39-46.doi:10.2307/3579193.
  • 7Simsek D,Jasin M. Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-1igase Ⅳ during chromosomal translocation formation[J].Nature Structural and Molecular Biology,2010,(04):410-416.
  • 8Nasiri M,Saadat I,Omidvari S. Genetic variation in DNA repair gene XRCC7 (G6721T) and susceptibility to breast cancer[J].Gene,2012,(01):195-197.
  • 9Shammas MA,Shmookler Reis R J,Koley H. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma[J].Blood,2009,(10):2290-2297.doi:10.1182/blood-2007-05-089193.
  • 10Kuznetsov SG,Haines DC,Martin BK. Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice[J].Cancer Research,2009,(03):863-872.doi:10.1158/0008-5472.CAN-08-3057.

引证文献4

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国外医学（放射医学核医学分册）
2005年 第3期

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