摘要
对X射线修复交叉互补(XRCC)基因功能的研究极大地促进了对哺乳动物DNA损伤修复过程和遗传不稳定性致癌机制的理解。通过观察XRCC基因突变体的表型,可以对其功能进行鉴定。目前已鉴定的这一基因家族的多数成员均参与几种重要的DNA修复途径,包括碱基切除修复、同源重组修复和非同源末端重接。XRCC基因的鉴定及其在DNA损伤修复和维持遗传稳定性过程中发挥重要的作用。
The researches on functions of X ray repair cross complementing(XRCC) genes had promoted the understanding of DNA damage repair processes and the mechanism of cancer induced by genetic instability. The functions of XRCC genes could be identified by studying their mutant phenotypes. Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining. The identification of XRCC genes and their functions took important parts in DNA damage repairs and genetic stability processes.
出处
《国外医学(放射医学核医学分册)》
2005年第3期132-136,共5页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词
X射线修复交叉互补基因
碱基切除修复
同源重组修复
非同源末端重接
X ray repair cross complementing genes
base excision repair
homologous recombination repair
non-homologous end joining