摘要
利用层析法分别从浙江、湖南和安徽产银环蛇毒中纯化得到的Ｋ－神经毒素（Ⅵ１ｂ和Ⅷ１ａ峰），分子量均为６５００．两个Ｋ一神经毒素在浓度１５０ｎｍｏｌ／Ｌ都能有效地阻断小鸡睫状神经节的烟碱传递，经２小时冲洗仍未见神经节传递功能的恢复。可以认为Ｋ一神经毒素是银环蛇蛇毒的基本成分。
Two Kappa-neurotoxins,peak Ⅵ 1b and peak Ⅷ 1a with a molecular weight of 6500dalton had been punfied frm Bungarus multicinctus Venom collected in Zhejiang、Hunan andAnhui pirovinces by chromatography. Both.K一NTs blocked the nicotinic transmission in the chick ciliary ganglion at a low concentration of 150nM,and no recovery was observed after 2houis' washing.It is concluded that Kappa一neurotoxinis are basic component of multicinctus venom.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1994年第3期130-136,共7页
Journal of Jinan University(Natural Science & Medicine Edition)
基金
国家自然科学基金资助项目
国务院侨办基金资助项目
关键词
K-神经毒素
银环蛇毒
睫状神经节
K一neurotoxin
neuronal nicotinic receptor
chick ciliary ganglion
