摘要
用牛血清白蛋白诱发了家兔实验性葡萄膜炎。汉防己甲素(Tet50mg/kg/dip)和地塞米松(Dex5mg/kg/dip)治疗8天,能显著降低眼部炎症反应、房水蛋白含量、血清免疫复合物和外周T淋巴细胞转化率。停止给药后4天,Dex组房水蛋白和血清免疫复合物再度升高。Tet组虽有升高,但比Dex组明显为低。病理学检查发现Tet组脉络膜炎症比对照组明显为轻。结果表明,Tet抑制实验性葡萄膜炎,除了其抗炎作用外,还与其抑制体液和细胞免疫反应有关。
Experimental
uveitis was induced in rabbits by bovine serum albumin。 Ocular inflammation, protein content
of aqueous humor,T lymphocyte transformation and serum circulatingimmune complex were
reduced markedly after the treatment of tetrandrine(Tet,50mg/kg/d,ip)and
dexamethasone(Dex,5mg/kg/d,ip)for 8 days。 Four days after withdrawal of Tet andDex the
protien content of the aqueous humor and serum ciucrlating immune complexes roseagain, but
these parameters in Tet group is lower than that in Dex group. The pathologicalstudy showed
that inflammation of choroid in Tet treated group was lighter than that in un-treated group.
These results suggest that Tet is an effective inhibitory agent on bovine serumalbunlin一
induced experimental uveitis。Its mechanism may be related to the suppression ofcellular and
humoral immune function aside from antiinflammation。
出处
《中华眼底病杂志》
CAS
CSCD
1994年第3期149-152,T012,共5页
Chinese Journal of Ocular Fundus Diseases