汉防己甲素对实验性葡萄膜炎的治疗作用及机制

THERAPEUTIC ACTIONS AND MECHANISM OF TETRANDRINE ON EXPERIMENTAL UVEITIS

用牛血清白蛋白诱发了家兔实验性葡萄膜炎。汉防己甲素（Ｔｅｔ５０ｍｇ／ｋｇ／ｄｉｐ）和地塞米松（Ｄｅｘ５ｍｇ／ｋｇ／ｄｉｐ）治疗８天，能显著降低眼部炎症反应、房水蛋白含量、血清免疫复合物和外周Ｔ淋巴细胞转化率。停止给药后４天，Ｄｅｘ组房水蛋白和血清免疫复合物再度升高。Ｔｅｔ组虽有升高，但比Ｄｅｘ组明显为低。病理学检查发现Ｔｅｔ组脉络膜炎症比对照组明显为轻。结果表明，Ｔｅｔ抑制实验性葡萄膜炎，除了其抗炎作用外，还与其抑制体液和细胞免疫反应有关。

Experimental uveitis was induced in rabbits by bovine serum albumin。 Ocular inflammation, protein content of aqueous humor,T lymphocyte transformation and serum circulatingimmune complex were reduced markedly after the treatment of tetrandrine(Tet,50mg/kg/d,ip)and dexamethasone(Dex,5mg/kg/d,ip)for 8 days。 Four days after withdrawal of Tet andDex the protien content of the aqueous humor and serum ciucrlating immune complexes roseagain, but these parameters in Tet group is lower than that in Dex group. The pathologicalstudy showed that inflammation of choroid in Tet treated group was lighter than that in un-treated group. These results suggest that Tet is an effective inhibitory agent on bovine serumalbunlin一 induced experimental uveitis。Its mechanism may be related to the suppression ofcellular and humoral immune function aside from antiinflammation。