期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

雄激素受体与激素非依赖性前列腺癌 被引量：4

下载PDF
导出
摘要 晚期前列腺癌可发生激素非依赖,对抗雄激素治疗不再有效。前列腺癌对雄激素依赖性发生变化的机制目前尚未阐明,近年来的研究显示前列腺癌雄激素非依赖性与雄激素受体(AR)的反常激活有关,与雄激素受体(AR)表达增加和突变、AR调节因子表达改变有关,细胞因子IL-6、IL-4,糖原合成激酶-3β参与激素非依赖性前列腺癌的AR激活。本文就这方面的研究进展作一综述。
作者 沈华锋 郑祥毅 谢立平
机构地区 [
出处 《国外医学（泌尿系统分册）》 2005年第4期461-465,共5页 Foreign Medical Sciences(Urology and Nephrology Foreign Medical Sciences)
关键词 前列腺肿瘤 受体 雄激素
分类号 R737.25 [医药卫生—肿瘤]
  • 相关文献

参考文献25

  • 1Santos AF, Huang H, Tindall DJ. The androgen receptor: a potential target for therapy of prostate cancer. Steroids,2004,69:79 - 85.
  • 2Chatterjee B. The role of the androgen receptor in the development of prostatic hyperplasia an d prostate cancer. Mol Cell Biochem, 2003,253: 89- 101.
  • 3Edwards J, Krishna NS, Grigor KM, et al. Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer. Br JCancer, 2003,89: 552- 556.
  • 4Ishiguro H, Uemura H, Fujinami K, et al. 55 kDa nuclear matrix protein (nmt55) mRNA is expressed in human prostate cancer tissue and is associated with the androgen receptor. Int J Cancer, 2003, 105:26- 32.
  • 5Chi KN, Gleave ME. Antisense approaches in prostate cancer. Expert Opin Biol Ther, 2004,4: 927 - 936.
  • 6O'Hara SM, Moreno JG,Zweitzig DR, et al. Multigene reverse transcription- PCR profiling of circulating tumor cells in hormone- refractory prostate cancer. Clin Chem,2004,50:826 - 835.
  • 7Halkidou K,Gnanapragasam VJ,Mehta PB,et al. Expression of Tip60,an androgen receptor coactivator, and its role in prostate cancer development.Oncogene, 2003,22: 2466- 2477.
  • 8Mu X, Chang C. TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC- 3.Prostate,2003,57:129- 133.
  • 9Lin HK,Hu YC,Lee DK,et al. Regulation of androgen receptor signaling by PTEN(phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Mol Endocrinol, 2004,18:2409 - 2423.
  • 10Wang L, Hsu CL, Ni J, et al. Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prost ate cancer cells. Mol Cell Biol,2004,24:2202- 2213.

同被引文献40

引证文献4

二级引证文献9

国外医学（泌尿系统分册）
2005年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部