1Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, Gassmann M, Gearhart JD, Lawler AM, Yu AY, Semenza GL. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor I alpha. Genes Dev 1998; 12:149-162.
2Peng J, Zhang L, Drysdale L, Fong GH. The transcription factor EPAS1/hypoxia -inducible factor2 alpha plays an important role in vascular remodeling. Proct Natl Acad Sci U S A 2000; 97:8386-8391.
3Tian H, Mcknight SL, Russell DW. Endothelial PAS domain protein I (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes Dev 1997; 11:72-82.
4Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev 2000; 14:1983-1991.
5Morrow CS, Cowan KH. Antineoplastic drug resistance and breast cancer. Ann NY Acad Sci 1993; 698:289-312.
6Wiesener MS, Turler H, Alien WE, William C, Eckardt KU, Talks KL, Wood SM, Garter KC, Harris AL, Pugh CW, Ratcliffe PJ,Maxwell PH. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1 alpha. Blood 1998; 92:2260-2268.
7Jain S, Maltepe E, Lu MM, Simon C, Bradfield CA. Expression of ARNT, ARNT2, HIF1 α, HIF2α and Ah receptor mRNAs in the developing mouse. Mech Dev 1998; 73:117-123.
8Ema M, 2ffaya S, Yokotani N, Sogawa K, Matsuda Y, Fujii-Kuriyama Y. A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor let regulates the VEGF expression and is potentially involved in lung and vascular develovment. Proct Natl Acad Sci U S A 1997: 94:4273-4278.
9Flamme I, Frohlich T, yon Reutem M, Kappel A, Damert A, Risau W. HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. Mech Dev 1997;63:51-60.
10Flamme I, Krieg M, Plate KH. Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF2 alpha. Am 1 Pathol 1998: 153:25-29.
7Mabjeesh NJ,Amir S. Hypoxia- inducible factor (HIF) in human tumorigenesis [ J ] . Histal Histopathal, 2007,22 (5) : 559 - 572.
8Huang LE, Gu J, Schau M. Regulation of hypoxia inducible factor - 1 alpha is mediated by an O2 - depenent degradation domain via the ubiquitin proteasome pathway [ J ]. Proc Natl Acad Sci USA,1998,95(14) :7987 -7992.
9Wang GL, Semenza GL. Characterization of hypoxia inducible factor - 1 and regulation of DNA dinding activity by hy- poxia [J]. Biol Chem,1993,265(29):21513 -21515.
10Kato Y,Asano K, Mogi T,et al. Clinical significance of circu- laxing vascular endothelial growth factor in dogs with mammarg gland tumors [J]. Vet Med Sci ,2007,69( 1 ) :77 - 80.
