c-erbB-2癌基因蛋白及ER、PR在乳腺癌中的表达及临床意义

Significance of the Expression of Oncogene C-erb B-2 and ER、PR in breast cancer

目的:探讨影响乳腺癌治疗及预后的相关因素。方法:采用免疫组化方法(LSAB法)检测乳腺癌C-erbB-2(Her-2/neu)蛋白及雌激素受体(ER)、孕激素受体(PR)在乳腺癌中的表达。结果:98例乳腺癌患者肿瘤组织的检测结果示C-erbB-2过度表达率与乳腺癌的组织学分级呈相关(P<0.05);ER、PR的阳性表达率分别为63.7%和60.2%;并与C-erbB-2过度表达率呈显著负相关(P<0.05)。结论:C-erbB-2蛋白及雌激素受体(ER)、孕激素受体(PR)的表达情况在一定程度上反应了乳腺癌的生物学行为,应有助于临床上乳腺癌治疗方案的选择及判断预后。

Objective:To investigate the protein expression of oncogene C-erb B-2 and ER?PR and its clinicopathologic significance in breast cancer. Method:Immunohistochemical staining,LSAB method,was used to detect the protein expression of oncogene C-erb B-2 and ER?PR. in 98 case of breast cancer. Results:The results showed that: Overexpression of C-erb B-2 was positively correlated with histological grading(P<0.05). Expression rate of ER,PR was 63.7% and 60.2%,respectively;and negatively correlated with overexpression rate of C-erb B-2(P<0.05).Conclusion:The protein expression of oncogene C-erb B-2 and ER?PR can be used as reference marker for jugging prognosis and planing the treatment programme of patients with breast cancer.