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347例乙型肝炎前S_1抗原与HBV免疫标志物的比较研究 被引量:1

A Comparative Study of Pre-S_1 Antigen and Hepatitis B Virus Immune Marker
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摘要 目的分析前S1抗原在不同HBV免疫标志中分布状态,了解其在HBV复制中的作用。方法用ELISA法检测前S1抗原和HBsAg、HBsAb、HBeAg、HBeAb、HBcAb。结果分布状态为HBsAg、HBeAb、HBcAb总阳性率为0.26>HBsAg、HBeAg、HBcAb总阳性率0.16。结论前S1抗原为一个反映HBV复制和传染性的良好指标。 Objective To analyze the distribution of pre-S_1 antigen in different hepatitis B virus (HBV) immune marker and investigate its functions in HBV replication.Methods The ELISA method was used to examine pre-S_1 antigen and HBsAg, HBsAb, HBeAg, HBeAb, HBcAb.Results Total positive rate (=0.26) of HBsAg, HBeAb, HBcAb was higher than that (=0.16) of HBsAg, HBeAg,HBcAb.Conclusion Pre-S_1 antigen is a good index to reflect the replication and contagion of HBV.
作者 肖康飞
出处 《医学文选》 2005年第3期320-321,共2页 Anthology of Medicine
关键词 前S1抗原 乙型肝炎病毒 病毒复制 酶联免疫吸附试验 Pre-S_1 antigen HBV Virus replication Enzyme linked immunosorbent assay
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  • 1Kuijpers L, Koens M, Lain MD, et al. Pre-S proteins in hepatitis B.J Med Virol, 1989, 28: 47.
  • 2Petit MA, Zoulim F, Capel F, et al. Variable expression of Pre-S1antigen in serum during chronic hepatitis B virus infection: an accurate marker for the level of hepatitis B virus replication. Hepatology,1990, 11: 809-814.
  • 3Yuki N, Hayashi N, Katayama K, et al. Quantitative analysis of PreS1 and Pre-S2 in relation to HBsAg expression. Hepatology, 1990,11: 38.
  • 4Pichoud C, Berby F, Stuyver L, et al. Persistence of viral replication after anti-HBe seroconversion during antiviral therapy for chronic hepatitis B. J Hepatol, 2000, 32: 307-316.
  • 5Haruna Y, Hayashi N, Yuki N, et al. PreS1 and PreS2 antigen as prognostic indexes for interferon treatment in patient with chronic hepatitis B. Scand J Gastroenterol, 1992, 27: 615-619.

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