乳腺癌C-erbB-2、PCNA的表达与激素受体的关系及其临床意义

The Expression of C-erbB-2 and PCNA in Breast Carcinoma and Their Relationship with Hormone Receptors and Their Clinical Significance

目的:探讨乳腺癌C-erbB-2癌基因和增殖细胞核抗原(Proliferatingcellnuclearantigen,PCNA)的表达与雌激素受体和孕激素受体的关系及其临床意义。方法:应用免疫组化S-P法检测85例乳腺癌组织中C-erbB-2、PCNA、ER和PR的表达。结果:85例乳腺癌组织中C-erbB-2、PCNA、ER和PR表达率分别为58.8%、56.5%、71.8%和67.1%。C-erbB-2和PCNA的表达在ER、PR阴性组高于ER、PR阳性组,在淋巴结转移组C-erbB-2和PCNA的表达高于淋巴结未转移组;C-erbB-2和PCNA的表达与ER、PR的表达呈显著负相关(P<0.05和P<0.01),与淋巴结的表达呈显著的正相关(P<0.01和P<0.05)。结论:C-erbB-2、PCNA与ER、PR在乳腺癌组织中有一定的内在联系,C-erbB-2与PCNA具有一定的协同作用,它们的检测结果对于乳腺癌内分泌治疗、辅助判断患者的预后具有重要意义。

Objective In order to understand the relationship of C-erbB-2 and PCNA overexpression to ER and PR in breast cancer and their clinical significance.Methods Immunohistochemistry S-P mothod was employed to detect the expressions of C-erbB-2,PCNA,ER and PR in breast carcinoma.Results The positive rates of C-erbB-2 ,PCNA ,ER and PR in breast carcinoma were 58.8% 56.5% ,71.8% and 67.06%,respectively.The positive rates of expression of C-erbB-2 and PCNA were higher in the group with positive expression of ER and PR than negative group ,and in the group with positive lymph node metastasis than non-lymph node metastasis group.C-erbB-2、PCNA expression was in negative correlation with ER、PR(P<0.05 and P<0.01).There was a correlation between C-erbB-2、PCNA and axillary lymph node metastasis (P<0.01 and P<0.05).Conclusions The expression of C-erbB-2 and PCNA is significantly correlated with ER and PR expression. The tests of c-erbB-2,PCNA,ER and PR are of importance in guiding endocrinous therapy and estimating prognosis.