阿托伐他汀对陈旧性心肌梗死病人心功能及运动耐量的影响

Effects of Atorvastatin on Cardiac Function and Exercise Tolerance in Patients with Old Myocardial Infarction

目的观察阿托伐他汀对血脂正常的陈旧性心肌梗死病人心功能及运动耐量的影响。方法选择57例陈旧性心肌梗死病人,随机分为两组,对照组给予硝酸异山梨酯(消心痛)10mg,口服,每日3次,连用8周,观察组给予阿托伐他汀10mg,口服,每日服1次,连用8周;比较两组每周心绞痛发作次数、硝酸甘油耗减量、心功能及运动耐量。结果阿托伐他汀可减少心绞痛发作次数、硝酸甘油耗减量,增加运动至出现ST段压低1mm所需时间、心绞痛所需时间,ST段缺血型下移之和明显减少;左室射血分数、心输出量、左室短轴缩短分数均增加,左室舒张末期内径无明显变化。结论阿托伐他汀改善运动诱发的心肌缺血,并提高心功能及运动耐量。

Objective To evaluate the effect of atorvastatin on cardiac function and exercise tolerance in patients with old myocardial infarction.Methods Fifty seven patients with old myocardial infarction were give nisosorbide dinitrate or atorvastatin for 8 weeks randomly.Exercise tolerance was evaluated by treadmill exercise testing, cardiac function by Doppler ultrasound respectively before and after therapy.Results After atorvastatin treating, frequency of angina pectoris attack and consumption of nitroglycerin weekly decreased significantly;the time for inducing angina and the time to 0.1mV ST segment depression,or ∑ST depression by exercise improved significantly(P<0.01).Left ventricular ejecting fraction,fractional shortening,cardiac output increased(P<0.01),and the left ventricular end-diastole diameter did not decreased (P>0.05).Conclusion Atorvastatin can improve myocardial ischemia,cardiac function and exercise tolerance induced by exercise.