2型糖尿病患者皮质醇与糖化血红蛋白检测的临床意义

The Clinical Significance of Cortisol and Glycosylated Hemoglobin(GhbA1c) Combinedly in Detecting in Patients with Type 2 Diabetes

目的:研究皮质醇(F)和糖化血红蛋白(GHbA1C)水平变化与2型糖尿病的相关性。方法:采用放射免疫分析(RIA)检测F、用层析法检测GHbA1C,用氧化酶法测定FBG。结果:F与GHbA1C的水平血糖控制较差组(A组)明显高于血糖控制较好组(B组)(P<0.01),且F水平与GHbA1C及FBG呈正相关(P<0.01),A组、B组F、GHbA1C水平均显著高于正常对照组(P<0.01)。结论:F及GhbA1C水平的检测有利于了解IDDM患者血糖疗效控制情况。

Objective To evaluate the clinical significance of cortisol and Glycosylated hemoglobin( GhbA1c) combinedly in detecting in patients with type 2 diabetes.Methods Blood cortisol levels were determined with RIA and GhbA 1c quantified with affinity chromatography,Blood fasting blood sugar (FBG) levels were determined with oxidase method.Results the blood levels of Cortisol and GhbA1c in diabetic group of poor glycaemic control (A group) were markedly higher than those in diabetic group of good glycaemic control(B group) (P<0.01).Furthermore, the cortisol levels were positively correlated to the blood GhbA1c and FBG lever (P<0.01).The blood levels of cortisol and GhbA1c in A and B groups were markedly highter than those in control group (P<0.01).Conclusion Combined determination of blood cortisol and GhbA1c levels is very important for detection of the glycaemic control in patients with type 2 diabetes.