洛汀新与安内真联合治疗高血压150例疗效观察被引量：2

Observation on Curative Effect of Hypertension Treated with Combination of Lotensin and Amlodipine

下载PDF

导出

摘要 Objective To compare the curative effect on treatment of combination of lotensin and amlodipine and alone with lotensin or amlodipine. Methods 371 cases of essential hypertension were divided into A lotensin and amlodipine group (150 cases), B lotensin group (105 cases ) and C amlodinpine group randomly and were treated respectively for 4 weeks. Ambulatory blood pressure monitoring was used to assess the anti-hypertensive efficacy, urine and renal function were also detected. Results The mean blood pressure in 24 h dropped in all three groups, but mean blood pressure in 24 h dropped significantly in group A. Group A was also superior to the others in reducing proteinaria and improving renal function. Conclusion Associated application with lotensin and amlodinpine not only had good efficacy in steadily controlling the blood pressure in EH cases but also improve renal function. Objective To compare the curative effect on treatment of combination of lotensin and amlodipine and alone with lotensin or amlodipine. Methods 371 cases of essential hypertension were divided into A lotensin and amlodipine group (150 cases), B lotensin group (105 cases ) and C amlodinpine group randomly and were treated respectively for 4 weeks. Ambulatory blood pressure monitoring was used to assess the anti-hypertensive efficacy, urine and renal function were also detected. Results The mean blood pressure in 24 h dropped in all three groups, but mean blood pressure in 24 h dropped significantly in group A. Group A was also superior to the others in reducing proteinaria and improving renal function. Conclusion Associated application with lotensin and amlodinpine not only had good efficacy in steadily controlling the blood pressure in EH cases but also improve renal function.

作者查滨孙久清赵明惠周殷

机构地区哈尔滨二四二医院

出处《黑龙江医学》 2005年第7期506-507,共2页 Heilongjiang Medical Journal

关键词内科学洛汀新安内真高血压 Lotensin Amlodinpine EH

分类号 R445.2 [医药卫生—影像医学与核医学]

引文网络
相关文献

参考文献5

1Staessen J A,Thils L,Bijittebier G,et al.Determing the trough to peak ratio in parallel group trials[J].Hypertension,1997,29(2):659～667.
2Dworkin L D,Bensten J A,Miriam Parker,et al.Calciumantagonists and converting enzyme inhibitors reduce renal injury by different mechanisms[J].Kidney Int,1993,43(4):808～814.
3Ray P E,Bruggeman L A,Horikoshi S,et al.Angiotensin Ⅱ stimulates human fetal mesanial cell proliferation and fibronectin biosynthesis by binding to AT1 receptors[J].Kideny Int,1994,45(1):177～184.
4Sabbatini M,Leonardi A,Testa R,et al.Effect of calcium antagonists on glomerular arterioles in spontaneously hypertensive rats[J].Hypertension,2000,35(3):775～779.
5Yasuaki D,Leoluca C,Karl P,et al.Angiotensin blockade or calcium antagonists improve endothelial dyfunction in hypertension:studies in perfused mesenteric resistance arteres[J].Cardoivasc Pharmacol,1994,24(3):372～379.