广州地区70对自然流产夫妇的细胞遗传学研究

Cytogenetics Analysis of 70 couples with spontaneous abortion.

目的对70对有自然流产史的夫妇进行细胞遗传学检查,探讨染色体异常与自然流产的关系。方法采用外周血淋巴细胞培养进行染色体核型分析。结果发现异常核型32例,其中倒位、平衡易位26例,说明染色体倒位、平衡易位是自然流产的主要原因。提示对不明原因的先兆流产不要盲目保胎,自然流产是检出染色体异常的重要临床指征,细胞遗传学对自然流产的诊治有重要的指导意义。结论孕前最好进行染色体检查,异常者应到优生遗传咨询门诊接受生育咨询与指导,孕后必须进行产前诊断,诊断结果病人可知情选择,以减少染色体异常儿出生,减少病人的痛苦,提高人口素质。

Objective:To analyze the chromosomal karyotype of 70 couples with spontaneous abortion,to study the relationship between chromosomal abnormality with spontaneous abortion.Methods:Detected chromosomal karyotypes of the patients by culturing peripheral blood lymphocytes,using G-banding techniques.Results: We discovered 32 cases of chromosomal abnormalities,including 26 cases of inversion,balanced translocation,which proved that inversion,balanced translocation of chromosome are the main reasons of spontaneous abortion.So the people with unknown reason of omen abortion can not keep the fetus blindly. Spontaneous abortion is one of the chromosomal abnormalities indications, cytogenetics will aim at the diagnosis and treatment of spontaneous abortion.Conclusion: Before pregnant,the couples should do the examination of chromosome,the chromosomal abnormality must accept procreateation of consultation and consultant at the department of prepotency consultation,in the first or second trimser,the couples must carry through prenatal diagnosis,at the same time the patient can choice whether to accept diagnosis result . Cytogenetics analysis to couples with spontaneous abortion can reduce the birth of chromosomal abnormality,reduce pain of the patient,and improve the population diathesis.