IL-8预测浅表性膀胱癌术后卡介苗灌注疗效

Significance of Interleukin-8 Monitoring during Post-operative Intravecical Instillation Bacillus Calmette-Guerin for Superficial Bladder Cancer

目的观察尿液白细胞介素-8(IL-8)测定评估浅表性膀胱癌术后卡介苗(BCG)灌注疗效。方法72例膀胱癌术后应用BCG膀胱灌注前后,应用免疫化学发光法测定尿液IL-8水平。结果并发症发生率为44.4%(32/72)。2例退出治疗,余70例中13例分别于6～18个月(平均13.6个月)复发,复发率18.6%。复发组BCG灌注后尿IL-8水平变化无显著差异(P>0.05);未复发组BCG灌注后尿IL-8显著高于灌注前(P<0.01)。结论尿液IL-8检测对BCG膀胱灌注预防浅表性膀胱癌复发的疗效预测有重要意义。

Objective To investigate the singificance of urinary Interleukin-8 monitoring during post-operative intravesical instillation bacillus calmette-guerin(BCG) for superficial bladder cancer.Methods 72 post-operative patients with superficial bladder cancer were treated with BCG 120mg mixed in 40 ml of normal saline instilled into the bladder via urethral catheter, once a week for six weeks,and then once a month,with the total course of treatment two years.Results The incidence of side effects was 44.4% (32/72), which the full course of instillation therapy could not be completed by two cases.With a median follow up of 13.6(range 6~18)months, the total tumor recurrence rate was 18.6%(13/70).After intravesical instillation Bacillus Calmette-Guerin therapy,the level of IL-8 in the urine showed no significant change in the recurrent group(P>0.05),but it increased significantly in the non-recurrent group after BCG perfusion (P<0.01).Conclusion IL-8 seems an effective indicator for investigation to its prognostic value for a clinical response to BCG therapy.