淡水淹溺致兔肺水肿模型肾素 丙二醛 心钠素 一氧化氮 血气等变化的研究

Study on the changes of AT_1,MDA,ANP,NO,RR in the PE-W rabbit

目的研究淡水淹溺致兔肺水肿模型(PE-W)发病后30min动脉血浆肾素(AT1)、丙二醛(MDA)、心钠素(ANP)、一氧化氮(NO)、呼吸频率(RR)、血气多点变化。方法将淡水灌入兔肺内复制出淡水淹溺肺水肿模型,于灌水前后30min取股动脉血查AT1、MDA、ANP、NO、血气,并记录RR。结果AT1、MDA、NO、RR显著异常(P<0·05),酸碱平衡及血氧正常,ANP无显著异常(P>0·05)。结论淡水淹溺致兔肺水肿早期,AT1增加并不导致ANP增加;尽管MDA增加较早,但由于机体自身调节能力,尚能维持血氧的正常,NO可能起到重要作用。

Objective To study the changes of AT1,MDA,ANP,NO and RR thirty minutes after PE-W.Methods We filled water in the lung of the rabbits to duplicate PE-W models and took the blood of femoral artery to test AT1,MDA,ANP,NO and blood gases and then recordered RR.Result AT1,MDA,NO and RR were abnormal (P<0.05),blood gases indicated the acid-base balance and the blood O2 was normal. ANP was not obviously abnormal. Conclusions In the earlier period of PE-W, the increase of AT1 can not lead to the increase of ANP.Though MDA increases earlier, the rabbit body adjusts itself.It can keep the blood gases normal. NO may play an important role.