山东省部分地区2003年健康人群A群 C群流行性脑脊髓膜炎抗体水平监测

Surveillance on Antibody Level Against Group A and C Epidemic Cerebro-spinal Meningitis Among Healthy Population in Shandong Province in 2003

目的了解山东省健康人群A群、C群流行性脑脊髓膜炎(流脑)抗体水平.方法 2003年对济南等5个市的健康人群血清,采用酶联免疫吸附试验(ELISA)方法进行了A群、C群流脑IgG抗体水平监测.结果 A群流脑抗体阳性率平均为81.98%(1 419/1 731),几何平均滴度(GMT)为1:17.52;各年龄组人群阳性率和GMT之间的差异有非常显著的统计学意义(χ2＝50.11,F＝16.23,P均＜0.01),＜3、20～39、40～岁组均低于平均水平.C群流脑抗体阳性率仅为7.89%(134/1 699),GMT为1:1.21,其中有6名≥15岁检测对象C群抗体滴度≥1:32,提示山东省可能存在C群脑膜炎球菌的自然感染.结论为进一步加强山东省流脑的控制工作,建议完善A群脑膜炎球菌多糖疫苗的免疫策略,同时开展A+C群脑膜炎球菌多糖疫苗接种的试点与观察工作.

Objective In order to explore the antibody level against group A and C epidemic cerebro-spinal meningitis among healthy population in Shangdong. Methods Sera from healthy population in 5 cities, Jinan etc., were collected and detected the serogroup A and C specific IgG antibody by ELISA in 2003. Results The results showed that the positive rate of serogroup A antibody was 81.98%(1419/1731) and the GMT was 1∶17.52.There were significant differentces for both antibody positive rates and GMTs among different age groups, χ2=50.11,F=16.23,(P<0.01), the antibody positive rate and GMT among<3,20～39 and 40-year-old groups were lower than the average level.The positive rate of serogroup C antibody was only 7.89%(134/17699) and the GMT was 1∶1.21.Serogroup C antibody titers of 6 persons above 15 years-old were ≥1∶32,which indicated that there could be nature infection of group C meningitidis in Shandong Province. Conclusion We suggested that the immunization to further control epidemic cerebro-spinal meningitis in Shandong Province should be improved.