川崎病并发冠状动脉病变的危险因素分析

The risk factor of Kawasaki disease with complication of coronary artery disease

目的探讨川崎病并发冠状动脉病变的危险因素。方法对60例确诊为川崎病患儿的临床表现,超声心动图、急性期C-反应蛋白、胆固醇、血沉、血小板、血红蛋白、白细胞等资料进行计量资料t检验、计数资料χ2检验、Logistic多元回归分析。结果60例川崎病并发冠状动脉病变18例(30%)。单因素分析显示:发热天数、血小板、C-反应蛋白、胆固醇与冠状动脉病变发生率有密切关系(P<0.01)。多因素Logistic多元回归分析显示:C-反应蛋白、胆固醇与冠状动脉病变密切相关(P<0.01)。结论对川崎病进行综合分析,可对该病作出及时的预后判断,予早期干预治疗,促进冠状动脉病变的恢复。

Objective To evaluate the risk factors of Kawasaki disease with complication of coronay artery distery disease.Methods Restrospective investigation of clinical behavior,ultrasonic cardiograms and blood test reslts of acute phrase (including the cholesterol,ESR,CRP, platelet,hemoglobin,leucocyte)in 60 patients with Kawasaki disease.Results Among 60 Cases,the complication of coronary artery disease is 18(30%).From single factor analysis,we find that fever durations, platelet,CRP, Choleterol have close relationship with the disease of coronary artery ( P <0.01).Multiple factors Logistic regression analysis indicate the CRP, Cholesterol have close relationship with the disease of coronary artery ( P <0.01).Conclusion We can assess the prognosis of the disease early and give appropriate treatment in advance to prevent coronary artery disease and to help the recovery of coronary artery by the analysis of risk factors.