低分子肝素钙、氯吡格雷治疗短暂脑缺血发作疗效观察

Clincal Observation of Curative Effect of Low Molecular Heparin and Clopidogrel in Transcient Ischemic Attack.

目的:观察低分子肝素钙与氯吡格雷治疗短暂性脑缺血发作(TIA)的疗效和安全性。方法:选择本院住院的60例TIA患者随机分为治疗组30例,给予低分子肝素钙(速碧林)0.4mL,每日2次,皮下注射,连用10d。停用后即给予氯吡格雷(波立维)75mg口服,每日一次,持续半年。对照组30例给予复方丹参滴注14d,同时口服肠溶阿斯匹林100mg,每日一次,持续半年。两组同时辅予胞二磷胆碱、ATP、CoA等药。结果:治疗组30例TIA发作在10d内完全控制随访半年无复发29例,有效率96.67%(29/30),无1例发展为脑梗死,无出血并发症。对照组30例TIA发作完全控制15例,有效率50.00%(15/30),有11例发展为脑梗死。两组比较有显著性差异(P<0.001)。结论:低分子肝素钙与氯吡格雷治疗TIA安全有效,不易复发,无明显副作用。

Objective:To observe the effect and safty of low molecular heparin and clopidogrel in treating transcient ischemic attack. Methods: 60 patients with TIA were enrolled in this study and randomly distributed into treatment group and control group, each group contained 30 patients . Treatment group were administered low melecular heparin 0.4mL, injected hypodermic, twice daily for 10 days,followed by clopidogrel 75mg, once daily orraly for half one year.Control group gave FuFangDanShen injection 20mL once daily intravenously for 14 days and intestine-dissovable Asprin 0.1 once daily at the same time for half year. The two group also administered CDPC、ATP and COA etc. Results:TIA attacks were controlled completely within 10 days in treatment group, no re-attacks in 29 cases after half a year's follow-up(29/30), the efficacy rate was reached up to 96.67%,none of 30 patients developed cerebral infarction and cerebral hemorrhage. In control group,TIA attacks were controlled completely in 15 of 30 cases(50%), 11 patients developed cerebral infarction . There was a significant differences between the two group(P<0.001).Conclusions: Low molecular heparin and clopidogrel are effective and safe in treatment of TIA, the reoccurrence rate is greatly decrease and no obvious drug side effect was observed.