阿法骨化醇胶丸联合碳酸钙片治疗慢性肾衰继发甲状旁腺功能亢进的疗效观察

Observation on Therapeutic Effect of Alfacalcidol Soft Capsules on Secondary Hyperparathyroidism Associated with Chronic Renal Failure

目的:观察阿法骨化醇胶丸联合碳酸钙片治疗慢性肾衰继发甲状旁腺功能亢进(SHPT)的疗效。方法:将55例慢性肾衰继发SHPT患者分为透析组(28例)和非透析组(27例),均在服用阿法骨化醇胶丸的同时加用碳酸钙片,连用3mo。观察治疗前、后血钙(Ca2+)、磷(P3-)、甲状旁腺激素(PTH)、碱性磷酸酶(AKP)、肌酐(Cr)的变化。结果:2组治疗后血Ca2+均明显升高(P<0.05),血PTH均明显下降(P<0.01)。结论:阿法骨化醇胶丸联合碳酸钙片治疗慢性肾衰继发SHPT早期患者安全、有效、经济。

OBJECTIVE:To investigate the curative effects of alfacalcidol soft capsules combined with calaium carbonate tablet on secondary hyperparathyroidism(SHPT)associated with chronic renal failure(CRF).METHODS:55patients were assigned to dialysis group(28cases)and non-dialysis group(27cases),both groups had taken oral alfacalcidol soft capsules in combination with calcium carbonate tablet continuously for3months.Then the changes in serum Ca 2+ ,P 3- ,PTH,AKP and Cr levels were observed.RESULTS:After treatment,serum Ca 2+ concentration was significantly increased(P<0.05),while serum PTH level was decreased remarkably(P<0.01)in both groups.CONCLUSION:Alfacalcidol soft capsules combined with calcium carbonate tablet to treat early SHPT is safe,effective,and economic.