促红细胞生成素治疗肾性贫血的疗效观察

Observation on Therapeutic Effects of Recombinant Erythropoietin on Anemia in Patients with Renal Chronic Failure

目的:观察促红细胞生成素治疗肾性贫血的疗效及不良反应。方法:128例肾性贫血患者皮下注射促红细胞生成素,疗程12wk,采用自身对照法观察临床治疗后情况。结果:显效91例,有效33例,总有效率为96.88%;不良反应有血压升高、透析器内凝血、注射部位疼痛、头痛,未发现严重不良反应;非透析治疗患者用药期间未见明显肾功能恶化。结论:促红细胞生成素治疗肾性贫血安全、有效。

OBJECTIVE:To observe the effects and side effects of recombinant erytropoietin(rEPO)on patients with anemia in chronic renal failure(CRF).METHODS:128 patients with anemia in CRF had been given rEPO by subcutaneous injection for12weeks,the clinical effects were observed by own control method.RESULTS:Excellence cases amounted 91,efficacy cases33,and the overall efficacy rate was96.88%;The side effects included hypertension,coagulation in dialysis machine,pain in injection site and head,no severe adverse drug reactions were found;No degradation in renal function was found in non-dialysis patients during the medication.CONCLUSIONS:rEPO could improve anemia in CRF safely and effectively.