二藤通痹合剂治疗类风湿性关节炎162例疗效观察

Erteng Tongbi Mixture for the Treatment of Rheumatoid Arthritis: An Clinical Observation of 162 Cases

目的观察二藤通痹合剂治疗类风湿性关节炎(RA)的临床疗效。方法162例RA患者服用二藤通痹合剂3个月,观察治疗前后晨僵时间、休息痛、20m步行时间、双手握力、肿胀关节数、压痛关节数,红细胞沉降率(ESR)、类风湿因子(RF)、C反应蛋白(CRP)等指标的变化。结果二藤通痹合剂总有效率为91.4%,无效8.6%。治疗后,患者的晨僵时间、休息痛、关节压痛和双手握力等症状明显改善,而20m步行时间和肿胀关节数无明显改善(P>0.05);ESR、RF、CRP有不同程度的下降,其中以RF最为显著(P<0.05)。结论二藤通痹合剂能有效改善RA的临床症状,通过调整机体免疫状况、减轻炎症等途径控制RA病情的进一步发展。

Objective To observe the clinical effect of Erteng Tongbi Mixture(ETM) on rheumatoid arthritis(RA). Methods 102 cases of RA were treated with ETM for 3 months. Time of morning stiffness, rest pain, 20m- walking time, hand grip, the number of joint with swelling and tenderness, erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C- reactive protein (CRP) were compared before and after the treatment. Results The total effective rate of ETM was 91.4 % and the ineffective rate 8.6 % . The morning stiffness, rest pain, hand grip and joint tenderness were obviously relieved, while 20m- walking time and the number of joint with swelling remained unchanged. ESR, RF and CRP were decreased to different extent, in particular RF(P < 0.05). Conclusion ETM is effective in relieving symptoms of RA and controlling the aggravation of RA by regulating the immune system and relieving inflammation.