血清视黄醇结合蛋白在肾脏疾病中的应用

Application of Serum Retinal-binding Protein in Diagnosis of Nephropathy

目的探讨血清视黄醇结合蛋白(sRBP)在肾脏疾病中的应用价值。方法在HITACHI7170全自动生化仪上采用免疫透射比浊法浊定sRBP,并进行相关的统计学分析。结果9组肾脏疾病患者sRBP的结果为:肾病综合征(161.57±83.68)mg/L,尿毒症(358.52±127.96)mg/L,系统性红斑狼疮肾病(164.49±106.98)mg/L,慢性肾功能衰竭(348.42±141.12)mg/L,糖尿病肾病(261.78±144.73)mg/L,慢性肾小球肾炎(274.69±129.97)mg/L,慢性肾功能不全(253.17±148.12)mg/L,急性肾盂肾炎(66.80±36.31)mg/L,高血压肾病(222.73±166.02)mg/L;对照组为(71.79±24.50)mg/L,除急性肾盂肾炎组外,各肾病组明显高于对照组(P<0.05)。比较常规血清肾功能检测项目,sRBP与sβ2-MG显著相关(P<0.01),系统性红斑狼疮肾病和慢性肾小球肾炎组sRBP与各项肾功能指标相关性好。结论sRBP可以作为反映肾脏滤过功能异常的较敏感指标。

Objective To evaluate the value of serum retinal-binding protein (sRBP) in diagnostic work-up of nephropathy. Methods sRBP was assayed by using immunological turbidimetry on HITACHI 7170. Results sRBP levels in the 9 types of nephropathy were: nephritic syndrome (161.57±83.68)mg/L, uremia (358.52±127.96)mg/L, systemic lupus erythematosus nephropathy (164.49±106.98)mg/L, chronic renal failure (348.42±141.12)mg/L, diabetic nephropathy (261.78±144.73)mg/L, chronic glomerulonephritis (274.69±129.97)mg/L, chronic renal dysfunction (253.17± 148.12 )mg/L, acute pyelonephritis (66.80±36.31)mg/L, hypertensive nephropathy (222.73±166.02)mg/L, and the healthy control was 71.79±24.50 mg/L. sRBP level was significantly higher in groups with nephropathy than that in the healthy controls (P<0.05), except the group with acute pyelonephritis. sRBP was significantly correlated with serum β_2-MG(P<0.01). Furthermore, sRBP was most closely correlated with other renal indices in systemic lupus erythematosus nephropathy and chronic glomerulonephritis than the others. Conclusions sRBP is a valid index in evaluation of nephropathy.