大学生接种不同剂量乙肝疫苗的免疫效果观察

Efficacy of Different Doses of HBV Vaccine Among College Students

目的对接种不同剂量乙肝疫苗的免疫效果进行分析,探讨对大学生进行乙肝疫苗接种的最佳剂量。方法我校02、03级新生2048人,随机分为A、B两组,分别用5μg×3和10μg×3的剂量接种重组酵母乙肝疫苗。结果B组抗-HBs阳转率84.42%(889/1053)高于A组阳转率61.61%(613/995),两组比较有非常显著性差异(P<0.01);女生抗-HBs阳转率76.05%(940/1236)高于男生69.21%(562/812),两者比较有非常显著性差异(P<0.01)。结论在大学生中进行乙肝疫苗全程免疫十分必要,接种剂量以10μg×3为宜。

Objective To study the efficacy of different doses of HBV vaccine and the best choice of dose for the college students. Method New comers of two grades during 2002 and 2003 in our college were randomly divided into groups A and B, Group A received inoculation with 5μg×3 of recombi-vax yeast HBV vaccine and Group B with 10μg×3; and altogether 2 048 new comers were enrolled in this study. Results The positive conversion rate of anti-HBs of the Group B students was 84.42% (889/1053), which was higher than that of Group A, which was only 61.61% (613/995), and significant difference (p< 0.01) existed between both groups. The positive conversion rate of anti-HBs among the girls was 76.05% ( 940 /1236), which was higher than that of the boys 69.21% (562/812), and highly significant difference existed (P< 0.01 ). Conclusion It is necessary for the students to be inoculated with HBV vaccine to obtain full-distance immunity, and it is better to be inoculated with the dose of 10μg×3.