奎的平与利培酮对首发精神分裂症患者脑电图影响的比较

The effect of quetiapine and risperidone on the EEG of first-episode schizophrenic patients

目的评价奎的平及利培酮对首发精神分裂症患者脑电图的影响。方法将60例首发精神分裂症患者随机分为两组,分别给予奎的平、利培酮治疗,疗程12周,于服药前及服药后4、8、12周末做脑电图检查,并分别用(PANSS)量表评定疗效。结果奎的平、利培酮治疗后脑电图异常率分别为33.3%、46.7%,两药差异无显著性,脑电图改变与疗效无关。结论奎的平、利培酮均可引起脑电图改变。

Objective To evaluate the effect of quetiapine and risperidone on the EEG of first-episode schizophrenic patients. Methods A total of 60 first-episode schizophrenic patients were randomly divided into two groups receiving quetiapine or risperidone for 12 weeks.Their EEG were detected before treatment and at the end of 4th、8th、12th week and the symptoms were rated with PANSS. Results The abnormal rates of the EEG in quatiapine group and risperidone group were 33.3% and 46.7% repectively,and there were no significant difference between two groups.The change of EEG had no relationship with the efficacy. Conclusion Quetiapine and risperidone may influence the EEG of the patients with first-episode schizophrenia.