西酞普兰合并氯丙咪嗪治疗难治性强迫症

Effect of citalopram administered with clomipramine for refractory obsessive-compulsive disorder

目的探讨西酞普兰以及西酞普兰合并氯丙咪嗪治疗难治性强迫症的疗效和不良反应。方法将16例难治性强迫症患者随机分为2组(n=8),分别给予西酞普兰,西酞普兰合并氯丙咪嗪治疗。采用耶鲁布朗强迫症量表(YBOCS)和副反应量表(TESS)评定疗效和副反应。结果西酞普兰合并氯丙咪嗪组的所有病人的YBOCS减分率均大于35%,有6例出现副反应。西酞普兰组仅有一例患者的YBOCS减分率大于35%,有3例出现副反应。结论西酞普兰合并氯丙咪嗪治疗难治性强迫症的疗效优于单用西酞普兰,但副反应明显多于西酞普兰组。

Objective To investigate efficacy and side effects of citalopram administered with clomipramine in the treatment of refractory obsessive-compulsive disorder (OCD).Methods A total of 16 patients with refractory OCD were divided into two groups treated with citalopram or citalopram plus clomipramine .All the patients were evaluated with Yale-Brown Obsessive Compulsive Scale(Y-BOCS) and Treatment Emergent Symptom Scale(TESS).Results In citalopram plus clomipramine group,all patients experienced decreasing rate in Y-BOCS score by at least 35%,6 patients were suffered from side effects.But in citalopram group,only one patient had such decreasing rate,3 patients suffered from side effects.Conclusion A combination of citalopram and clomipramine would appear to be more useful than citalopram in the treatment of refractory OCD,while its side effects were significantly more than those of citalopram.