厄贝沙坦治疗高血压并左心室肥厚疗效分析

Clinical Efficacy of Lrbesartan in Left Ventricular Hypertrophy in Patients with Hypertension

目的评价厄贝沙坦治疗高血压病并左心室肥厚(LVH)的临床疗效及安全性。方法52例伴左心室肥厚的高血压患者随机分为厄贝沙坦组26例,0.15～0.3g,1次/d,口服;氨氯地平组(对照组)26例,5～10mg,1次/d,口服。两组均连续服药半年。观察用药前后偶测血压、动态血压(ABPM)、左心室舒张末内径(LVDD)、舒张期室间隔厚度(IVST)及左心室后壁厚度(LVPWT)等项目。结果两组用药后降压总有效率分别为84.6%(22/26)和80.7%(21/26);降压幅度(偶测血压)分别为(26.5±3.7)/(16.1±3.3)mmHg和(26.4±4.6)/(15.8±3.8)mmHg;收缩压和舒张压的谷/峰比值分别是82%和80%、76%和72%;两组左心室室壁厚度、左心室重量和左心室重量指数均比用药前有显著下降,两组用药前后差异有统计学意义(P<0.01),但组间比较差异无统计学意义(P>0.05)。结论厄贝沙坦可有效降低高血压,并逆转LVH,与氨氯地平疗效相近,不良反应发生率低,其安全性及耐受性均较高,值得临床推广应用。

Objective:To evaluate the efficacy and safety of Irbesa rt an on left ventricular hypertrophy in patients with hypertension.Methods:Fifty-two patients with hypertension and left ventricular hypertrophy were divided int o two groups randomly(twenty-six each group):irbesartan group took 0.15~0.3 g o rally,once a day;amlodipine group took 5~15 mg,orally.Two groups continuously to ok their medicines for half a year.The items such as blood pressure random monit oring, ambulatory blood pressure monitoring(ABPM),Left ventricular diastolic dia meter(LVDD),interventricular septal thick(IVST)and left ventricular posterior wa ll thick(LVPWT)were observed before and after taking the medicine.Results:After treatment,the total therapeutic effect rate in irbesartan group was 84.6%(22/26) .While the rate in amlodipine group was 80.7%(21/26).Lowering range(blood pressu re random monitoring)were(26.5±3.7)/(16.1±3.3)mmHg and(26.4±4.6)/(15.8±3 .8)mmHg respectively;T/P of systolic pressure(SBP)and diastolic pressure(DBP)w e re 82%, 80%,76% and 72% respectively.Left ventricular posterior wall thick,Lef t ventricular mass and Left ventricular mass index of two groups all drop greatl y compared with those before taking medicine.The difference between before and a fter taking medicine had statistics meaning(P<0.01).But the difference be tween the groups showed no significant statistics meaning(P>0.05).Conclusio n:Irbesartan appears to be a safe and effective drug in the treatment of left ve ntricular hypertrophy in patients with hypertension.Irbesartan may rapidly and effectively lower blood pressure and significantly reduce left ventricular h ypertrophy,which is similar to the effects of amlodipine.Its side effects are mo dest. It is worth popularizing into practice.