摘要
目的观察川芎嗪辅助治疗对原发性肾病综合征患者血流状态的影响。方法对照组常规激素(泼尼松1mg·kg-1·d-1)治疗;治疗组在常规激素治疗的基础上给予川芎嗪(400～600mg·次-1·d-1)加入5%葡萄糖溶液500ml中静脉滴注,14d为1疗程。观察两组在治疗前后血液流变学、血脂及肾功能等指标的变化。结果治疗组全血比黏度(高切及低切)、血浆比黏度、红细胞聚集指数、血沉、血脂及肾功能等指标均比对照组有显著改善(P<0.05～0.01)。结论川芎嗪辅助治疗原发性肾病综合征可明显改善其高血黏度、高血凝滞、高血脂症及肾功能。
Objective:To study the effects of Ligustrazine on blood rheology in Nephrotic syndrome.Methods:Nephrotic syndrome patients were randomly divided into two groups. Based on the regular prednisone therapy, the treated group was given Ligustrazine (400～600 mg/d), totally for 14 days. Haemorheology indices, Fibrinogen and Cholesterol were observed.Results:Flushing dose of Ligustrazine treatment significantly reduced the haemorheological indices, Fibrinogen and Cholesterol in Nephrotic syndrome patients(P<0.05～0.01).Conclusion:Flushing dose of Ligustrazine treatment may ameliorate the blood state with 'high viscosity','high aggregation'and 'high concentration' in patients with Nephrotic syndrome.
出处
《中国中西医结合肾病杂志》
2005年第7期393-394,共2页
Chinese Journal of Integrated Traditional and Western Nephrology
基金
广东省中医药管理局基金资助项目(No.103125)
