抑癌基因DPC4与胰腺癌的研究进展

Advances of the Relationship Between Tumor Suppressor Gene DPC4 and Pancreatic Carcinoma

目的介绍抑癌基因胰腺癌缺失基因(DPC4)的改变与胰腺癌的发展及预后的关系。方法复习近几年的相关文献,进行综述。结果抑癌基因DPC4位于18号染色体上,其编码产物为Smad4蛋白。Smad4蛋白是转移生长因子β信号传导通路的中心分子,所有生物学效应都是Smad4蛋白与不同的Smads蛋白相互作用的结果。约有50%的胰腺癌发生DPC4基因的缺失或失活,DPC4基因的表达缺失与胰腺癌的发展及预后有密切关系。结论抑癌基因DPC4的改变与胰腺癌的发展及预后有密切关系,但仍需进行深入研究。

Objective To investigate the relationship between tumor suppressor gene DPC4 and the development and prognosis of pancreatic carcinoma. Methods Relevant literatures of recent years were reviewed. Results DPC4 was located on chromosome 18. Its product was Smad 4 protein. Smad 4 protein was the central component of the transforming growth factor-beta signaling pathway, and all the biological effect was the results of interaction of Smad 4 and different Smads. The gene was deleted or inactive in about 50% of pancreatic carcinomas. The deletion of DPC4 had a great relation to the development and prognosis of pancreatic carcinoma. Conclusion The alteration of tumor suppressor gene DPC4 is connected with the development and prognosis of pancreatic carcinoma. However, this research should be further studied.