柯萨奇B组病毒感染与云南省地方性猝死的关系

Relationship between Coxsackievirus B infection and Yunnan endemic sudden cardiac death in Yunan Province

目的探讨柯萨奇B组病毒(CoxsackievirusB,CVB)感染与云南省地方性猝死的关系。方法根据流行病学现场调查和临床检查资料,在病区设立病例组和内对照组,在非病区设立外对照组。酶联免疫法(ELISA)检测3组人群近期CVB感染情况及CVB阳性患者CVB1～6型的分布。结果CVB非特异性IgM抗体阳性率在内对照组为88.5%,外对照组为29.2%,两组之间差异有统计学意义(χ2=33.975,P<0.01);病区CVB非特异性IgM抗体阳性率在病例组为92.0%,内对照组为88.5%,两组之间差异无统计学意义(χ2=0.248,P>0.05)。CVB阳性患者亚型分布,在病区内以CVB5(53.3%)、CVB6(34.8%)为主,CVB3未检出,CVB1(2.2%)、CVB2(1.1%)、CVB4阳性患者(8.7%)有少量检出;在非病区内以CVB1(42.9%)为主,CVB3、CVB5未检出。结论CVB感染与云南省地方性猝死有一定的关联,CVB感染是云南省地方性猝死的可疑危险因素。

Objective To investigate the relationship between CVB and endemic sudden cardiac death inYunan province (YESCD). Methods With the data from field epidemiological study and clinical examination, thecases of YESCD and controls were grouped. The levels of antibody IgM of CVB were measured with Elisa test Kit.Results The positive rates of nonspecific antibody IgM of CVB were significantly different(χ2 = 33.975, P < 0.01)between the controls in disease area (88.5%) and non-disease area (29.2%) , however they were not significantlydifferent(χ2 = 0.248, P > 0.05) between the cases of YESCD(92.0%) and the controls in disease area(88.5%). Indiseased area, CVB5(53.3%) and CVB6(34.8%) were predominant types; CVB3 was not detected; CVB1(2.2%),CVB2 (1.1% ) and CVB4 (8.7% ) were rarely detected. While in non-disease area, CVB1 (42.9% ) was apredominant type; CVB3 and CVB5 were not detected. Conclusions There may be an association between CVBand YESCD, CVB infection was a potential risk factor of YESCD.