Pyrroloquinoline quinone enhances regeneration of transected sciatic nerve in rats

Pyrroloquinoline quinone enhances regeneration of transected sciatic nerve in rats

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摘要 Objective: To investigate the effect of pyrroloquinoline quinone (PQQ) on nerve regeneration of transected sciatic nerve in animal models.Methods: Forty SD rats weighing 220-240 g were randomized into a PQQ group (n=20) and a control group (n=20). Each animal underwent sciatic nerve transection operation. After the operation, PQQ 0.5 ml ( 250 μg/Kg) was injected at the operation site in the PQQ group, while the same volume of normal saline was delivered in the control group. Nerve functional evaluation, electrophysiological index recording were carried out according to the experimental design. Newly generated nerve specimens were harvested 12 weeks postoperatively for morphological studies. Results: In the PQQ group there was a good nerve regeneration and the sciatic nerve function, sciatic nerve function index, electrophysiological index and morphological appearance were superior to the control group (P< 0.05).Conclusions: PQQ has a remarkable effect in enhancing nerve regeneration of transected peripheral nerve. Objective: To investigate the effect of pyrroloquinoline quinone (PQQ) on nerve regeneration of transected sciatic nerve in animal models.Methods: Forty SD rats weighing 220-240 g were randomized into a PQQ group (n=20) and a control group (n=20). Each animal underwent sciatic nerve transection operation. After the operation, PQQ 0.5 ml ( 250 μg/Kg) was injected at the operation site in the PQQ group, while the same volume of normal saline was delivered in the control group. Nerve functional evaluation, electrophysiological index recording were carried out according to the experimental design. Newly generated nerve specimens were harvested 12 weeks postoperatively for morphological studies. Results: In the PQQ group there was a good nerve regeneration and the sciatic nerve function, sciatic nerve function index, electrophysiological index and morphological appearance were superior to the control group (P< 0.05).Conclusions: PQQ has a remarkable effect in enhancing nerve regeneration of transected peripheral nerve.

作者李皓桓刘世清彭昊张弩

机构地区 Department of Orthopedics

出处《Chinese Journal of Traumatology》 CAS 2005年第4期225-229,共5页 中华创伤杂志（英文版）

关键词苯醌坐骨神经小鼠动物实验 Peripheral nerves Nerve regeneration Pyrroloquinoline quinone

分类号 R651.3 [医药卫生—外科学]

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Chinese Journal of Traumatology

2005年第4期

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Pyrroloquinoline quinone enhances regeneration of transected sciatic nerve in rats

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