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冠心病合并2型糖尿病患者血脂检测 被引量:6

Serum levels of lipid in patients with coronary heart disease and non-insulin dependent diabetes mellitus
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摘要 目的:观察冠心病(CHD)合并2型糖尿病患者血脂水平的变化,并探讨CHD合并2型糖尿病的危险性与脂质代谢紊乱间的相关性.方法:检测CHD组患者29(男18,女11)例,年龄40~70(平均55.2)岁;CHD合并2型糖尿病组[CHD伴非胰岛素依赖型糖尿病(NIDDM)]患者22(男12,女10)例,年龄41~70(平均56.5)岁;正常对照组[健康献血员31(男17,女14)例,年龄38~50(平均43.5)岁]的血脂水平.结果:CHD伴NIDDM组患者总胆固醇(TC),三酰甘油(TG),低密度脂蛋白胆固醇(LDLC)和载脂蛋白B(ApoB)水平明显高于CHD组患者[TC:(5.87±1.02)mmol/Lv(4.10±1.13)mmol/L;TG:(2.10±1.05)mmol/Lv(1.13±0.85)mmol/L;LDLC:(4.23±0.97)mmol/Lv(2.97±0.90)mmol/L;ApoB:(0.90±0.18)mmol/Lv(0.58±0.19)mmol/L,均P<0.01],但CHD伴NIDDM组患者高密度脂蛋白胆固醇(HDLC),载脂蛋白A1(ApoA1)水平明显低于CHD组患者[HDLC(0.71±0.12)mmol/Lv(0.94±0.16)mmol/L,ApoA1:(0.73±0.19)mmol/Lv(1.03±0.20)mmol/L,均P<0.01].结论:CHD合并2型糖尿病患者在脂质代谢紊乱方面存在更多致CHD的危险因素,应重视这类患者的血脂检测并及时纠正脂质代谢紊乱,以降低CHD的危险性.
出处 《第四军医大学学报》 北大核心 2005年第13期1243-1244,共2页 Journal of the Fourth Military Medical University
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参考文献6

  • 1Orcards TJ.Dyslipoproteinmia and diabetes[J].J End Metab Clin,1990;12(3):361-363.
  • 2Grundy SM,Bedcdker RND,Clark LT,et al.Expert panel on detection,eveuatioon,and treatment of high bolld cholesterol in adults.Executive summary of the third report of the national cholesterol education program(NECP) expert panel on detection,wvaluation ,and treatment of high blood cholesterol in adults(Adult treatment panel Ⅲ)[J].JAMA,2001;285(19):2486-2497.
  • 3Picard S.Lipoprotein glyco oxidation[J].Diabete Metab,1995;21(2):89-94.
  • 4Anding JD,Kubena KS,McIntosh WA,et al.Blood lipids,cardiovascular fitness,obesity,and blood pressure:The presence of potential coronary heart disease risk factors in adolescents[J].J Am Diet Assoc,1996;96(3):238-242.
  • 5陈晓平,杨文英,卜石,萧建中,刘雪莉,王娜,赵文惠.罗格列酮和二甲双胍对高脂饲养造成的胰岛素抵抗的影响[J].中华内科杂志,2004,43(4):280-283. 被引量:65
  • 6Gami AS,Montori VM,Erwin PJ,et al.Systematic review of lipid lowering for primary prevention of coronary heart disease in diabetes[J].BMJ,2003;326(7388):528-529.

二级参考文献13

  • 1杨文英,邢小燕,林红,马晓华,胡英华,李光伟,潘孝仁.高甘油三酯血症是非胰岛素依赖型糖尿病发病的危险因素──432例非糖尿病人群六年前瞻性观察[J].中华内科杂志,1995,34(9):583-586. 被引量:143
  • 2Storlien LH, James DE, Burleigh KM, et al. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol, 1986, 251(5 Pt 1):E576-E583.
  • 3McGarry JD. Banting lecture 2001:dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes,2002,51:7-18.
  • 4Lee Y,Hirose H, Ohneda M,et al. Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships. Proc Natl Acad Sci U S A, 1994,91: 10878-10882.
  • 5Randle PJ,Garland PB,Hales CN, et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 1963,1: 785-789.
  • 6Boden G, Chen X, Ruiz J, et al. Mechanism of fatty acid-induced inhibition of glucose uptake. J Clin Invest, 1994, 93: 2438-2446.
  • 7Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and huperinsulinemia. J Clin Endocrinol Metab, 2001,86:1930-1935.
  • 8Maeda N, Shimomura I, Kishida K, et al. Diet-induced insulin resistance in mice lacking adiponetin/ACRP30. Nat Med, 2002, 8:731-737.
  • 9Yamauchi T, Kamon J, Waki H, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med, 2001, 7:941-946.
  • 10Combs TP, Berg AH, Obici S, et al. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest, 2001,108:1875-1881.

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