摘要
目的:研究成人1型糖尿病患者血清中抗IA-2抗体和抗GAD65抗体的水平并进行分析。方法:用ELISA法检测了48例20～45岁,病程小于2年的1型糖尿病患者组血清中的IgG型抗IA-2抗体和抗GAD65抗体,并以110例正常人血清作对照组。结果:患者组血清中抗IA-2抗体和抗GAD65抗体的水平与对照组差别均有统计学意义,而且患者组血清中抗IA-2抗体较抗GAD65抗体有更高的阳性率。结论:成人新发1型糖尿病患者血清中IgG型抗IA-2抗体和抗GAD65抗体均有不同程度明显升高,而且对两者进行联合检测会更有助于临床上1型糖尿病的早期诊断。
Objective To study the level of serum anti-IA-2 antibody and to compare it with that of anti-GAD antibody in type I diabetic patients. Methods Using ELISA method the serum levels of anti-IA-2 IgG and anti-GAD65 antibody were detected in 48 type 1 diabetic patients aged from 20 to 45.These patients had been diagnosed diabetes in the recent 2 years. At the same time the antibody in 110 healthy people was also detected as control. Results There was significant difference in the level of serum anti-IA-2 IgG between the patients and controls. Compared with anti-GAD65 anti-IA-2 showed higher positive rate. Conclusion Anti-IA-2 IgG was significanfly elevated in type 1 diabetic patients and showed higher positive rate than anti-GAD65 IgG. Analysis of anti-IA-2 antibody and anti-GAD antibody would help with the early diagnosis and classification of type 1 diabetes.
出处
《天津医药》
CAS
北大核心
2005年第7期401-402,共2页
Tianjin Medical Journal
基金
天津市21世纪自然科学基金(项目编号:973706611)
