纤溶和凝血因子在急性肺血栓栓塞症发病机制中的作用

Study on Plasma Concentration of Coagulation and Fibrinolytic Parameters in Acute Pulmonary Thromboembolism

目的:测定急性肺血栓栓塞症(APT)患者凝血和纤溶因子的血浆含量,探讨其在发病机制中的作用。方法:对44例APT患者(APT组)和56例健康查体者(对照组)应用酶联免疫吸附双抗体夹心法(ELISA法)定量测定血浆tPA、PAI-1、PC、FPS和vWF∶Ag抗原水平。结果:与对照组相比,APT组tPA、PAI-1和vWF∶Ag血浆含量水平较高,FPS水平较低,且差别有显著统计学意义。结论:PAI-1及vWF∶Ag产生、释放增多和FPS血浆含量减低在急性肺血栓栓塞症的发病机制中具有重要作用。

Objective To explore the changes and the roles of coagulation and fibrinolytic parameters in acute pulmonary thromboembolism APT. Methods The antigen levels of tPA,PAI-1,PC,FPS and vWF∶Ag were quantified by a commercially available enzyme-linked immunosorbent assay ELISA respectively in various therapytic periods of 44 APT cases and 56 healthy control cases. Results APT patients had higher levels of tPA,PAI-1 and vWF antigen and lower levels of FPS before the starting of therapy than thoes of healthy-control group. Conclusions Increased PAI-1 and vWF antigen levels and decreased FPS level in plasma may contribute to the incidence of APT.