PCNA、MMP9和E-cd在膀胱移行上皮癌中表达及意义

Expression and Significance of PCNA, MMP9 and E-cd in Transitional Cell Carcinoma of Bladder

目的:探讨PCNA、MMP9和E-cd在膀胱移行细胞癌(BTCC)中的表达及意义。方法:用免疫组织化学方法检测73例BTCC及11例正常膀胱黏膜中PCNA、MMP9和E-cd的表达。结果:PCNA、MMP9和E-cd在正常膀胱黏膜与不同病理分级和临床分期的BTCC中的表达有显著性差异。MMP9、PCNA的阳性表达随着BTCC病理分级和临床分期的升高而增高。E-cd的阳性表达率随着肿瘤的病理分级和临床分期的升高而降低。PCNA、MMP9和E-cd两两之间在BTCC中的表达亦有显著性差异(P<0.05或P<0.01)。结论:PCNA、MMP9和E-cd的表达,与BTCC的生物学行为关系密切,并可多因素参与膀胱癌的生物学行为。

Objective To study the expression and significance of PCNA MMP9 and E-cd in transitional cell carcinoma of bladder BTCC. Methods The immunohistochemical stainning method was used to evaluate the PCNA MMP9 and E-cd in 73 cases of transitional cell carcinoma of bladder. Results The positive rates of these three expression products were as follows 60.3%PCNA 27.4%MMP9 and 56.2%E-cd. The expressions of PCNA and MMP9 were found to be positively correlated to the pathological grade and the clinical staging of BTCC. The expression of E-cd was found to be negatively correlated to pathological grade and the clinical staging of BTCC. Conclusion The results suggest that PCNA MMP9 and E-cd play important roles in the occurrence and development of BTCC. Multiple factors are assayed for pathological diagnosis prognosis and treatment in BTCC.