摘要
目的探讨重庆地区汉族遗传因素对哮喘发病的影响。方法采用病例-对照研究方法进行哮喘遗传流行病学调查。结果重庆哮喘先证者一级亲属遗传度为(80·56±5·68)%;哮喘患者分离比为0·18;一级亲属的相对危险度为7·38,同胞对的相对危险度4·47。结论重庆地区哮喘遗传方式符合多基因遗传方式,遗传因素是哮喘发病的主要危险因素;可用定位克隆的方法对哮喘易感基因进行定位研究。
Objective To investigate the genetic faction influence on asthmatic patients in Chongqing, China. Methods Case-control study was employed for genetic epidemiological survey. Results The heritability of asthma in Chongqing was (80.56±5.68)% in first-degree relatives of asthma probands. The segregation ratio was 0.18. The relative risk of first-degree relatives and siblings of asthma probands were 7.38 and 4.47, respectively. Conclusion The inheritance pattern of asthma in Chongqing coincided with polygenic inheritance pattern. Genetic factor is a major risk factor of asthma. The relative risk in siblings is high. We can localize the susceptible gene of asthma with positional cloning.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2005年第13期1394-1396,共3页
Journal of Third Military Medical University
关键词
哮喘
遗传流行病学
遗传度
相对危险
asthma
genetic epidemiology
heritability
relative risk
