丙酸氟替卡松联合盐酸班布特罗治疗儿童哮喘疗效观察

Efficacy of fluticasome propinate combined with bambuterol hydrochloride in treatment of asthma in children

目的:观察丙酸氟替卡松加盐酸班布特罗防治儿童哮喘的疗效。方法:将32例中度哮喘患儿随机分成两组。治疗组18例采用丙酸氟替卡松吸入加盐酸班布特罗口服,对照组14例单用丙酸氟替卡松吸入,观察两组治疗前及治疗4、8、12周后日夜间哮喘症状评分,对22例患儿于治疗前及治疗12周后监测最大呼气峰流速值(PEF)。结果:两组日夜间哮喘症状评分于治疗4、8、12周后均有显著改善,且在以后的治疗中得到持续改善,治疗组优于对照组(P<0.01);两组PEF于治疗后也有显著改善(P<0.01),但差异无显著性(P>0.05)。结论:丙酸氟替卡松吸入加盐酸班布特罗口服治疗儿童哮喘疗效显著。

Objective:To observes the therapeutic effect of fluticasone propinate inhalation plus bambuterol hydrochloride in the prevention and treatment of asthma in children.Methods:Thirty-two children with moderate asthma were divided into two groups at random.Treatment group(18 cases) were administered fluticasone propinate inhalation plus bambuterol hydrochloride.Control group(14 cases) were given fluticasone propinate inhalation only.The daytime and night asthma symptom scores were observed before treatment and 4 weeks,8 weeks and 12 weeks after treatment.The peak expiratory flow(PEF) of 22 cases before treatment and 12 weeks after treatment were easured.Results:The scores of daytime,night asthma symptom 4 weeks,8 weeks and 12 weeks after treatment were significantly different from those before treatment(P<0.01),and the symptoms gradually improved with the treatment,which was more obvious in the treatment group than in the control group(P<0.01).PEF were significantly different between pre-treatment and 12 weeks after treatment(P<0.01),but treatment group and control group was no sighifcantly diffrent(P>0.05).Conclusions:Fluticasone propinate inhalation combined with bambuterol hydrohloride is effective for treatment of asthma in children.