摘要
背景与目的:探讨刺五加对小鼠Lewis肺癌侵袭转移干预作用的效果。材料与方法:Lewis肺癌C57/BL雌性小鼠分成刺五加+环磷酰胺组、环磷酰胺组、刺五加组和肿瘤组,通过检测各组小鼠的瘤重和抑瘤率,应用酶联免疫吸附试验(Enzyme-linkedimmunosorbentassay,ELISA)法检测血浆、瘤和肺组织中I型纤溶酶原激活剂抑制剂(Plasminogenactivatorinhibitor-Ⅰ,PAI-1)、尿激酶型纤溶酶原激活剂(uroleinasetypePlasminogenActivator,uPA)活性观察刺五加对Lewis肺癌的干预作用。结果:刺五加较肿瘤组瘤重、血浆和瘤,肺组织中PAI-1、uPA活性明显降低。结论:刺五加有抑制肿瘤生长、减少瘤、肺组织和血浆中uPA、PAI-1活性,对实验性小鼠肺癌侵袭转移过程中显示出了一定的干预作用。刺五加适于被开发为常规抗癌辅助药物。刺五加+环磷酰胺组的效果比单独用环磷酰胺或刺五加的效果更好。
BACKGROUND&AIM: To study the intervene role of acanthopanax sentiocosus(APS)in mice Lung during mice Lewis lung cancer. MATERIAL AND METHODS: Lewis lung cancer C57/BL mice were divided into acanthopanax senticasus+cyclophosphemide(CP),cyclophosphemide,acanthopanax sentiocosus and tumor groups.The tumor weight and inhibitory rate of each group were detected by elisa,PAI-1and uPA activation. RESULTS: The content of PAI-1,uPA of plasma and tumor,lung of APS group mice was significantly lower than tumor group in each time. CONCLUSION: APS exhibited intervention effects on the invasion and metastasis of cancer,and mice in APS plus CP group were getting better than APS alone group and CP alone group.
出处
《癌变．畸变．突变》
CAS
CSCD
2005年第4期217-219,共3页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
河北省自然科学基金资助(No.399392)
