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勃起神经递质血管活性肠多肽的研究进展 被引量：2

Progress in the Studies of Vasoactive Intestinal Polypeptide
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摘要 血管活性肠多肽(VIP)是主要的勃起神经递质之一,当阴茎勃起时VIP被释放,参与阴茎勃起调控。随着对VIP调控阴茎勃起机制不断深入的研究,VIP供体、VIP基因转导在治疗勃起功能障碍方面将有巨大的临床应用前景。 Vasoactive instestinal polypeptide (VIP) is a potent vasodilator and smooth muscle relaxant, and also fulfils several of the criteria for a neurotransmitter mediating penile erection. VIP donor and gene transfer of VIP are a potentially promising and physiologically relevant strategies for the treatment of erectile dysfunction.
作者 沈周俊
机构地区 浙江大学医学院附属第一医院泌尿外科
出处 《中华男科学杂志》 CAS CSCD 2005年第7期483-485,共3页 National Journal of Andrology
关键词 血管活性肠多肽 勃起功能障碍 <Keyword>vasoactive intestinal polypeptide erectile dysfunction
分类号 R33 [医药卫生—人体生理学]
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参考文献11

  • 1Andersson PO, Bloom SR, Mellander S. Haemodynamics of pelvic nerve induced penile erction in dog possible mediation by vasoactive intestinal polypepstide[ J]. J Physiol, 1984, 350:209-224.
  • 2Said SI, Mutt V. Polypeptide with broad biological activity: isolation from small intestine[J]. Science, 1970, 169(951 ) :1217-1218.
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  • 5Hedlund P, Alm P, Ekstrom P, et al. Pituitary adenylate cyclase-activating polypeptide, helospectin, and vasoactive intestinal polypetide in human corpus cavernosum [ J ]. Br J Pharmacol,1995, 116(10) :2258-2266.
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  • 7Vanhatalo S, Parkkisenniemi U, Steinbusch HW, et al. No colocalization of immunoreactivities for VIP and neuronal NOS, and a differential relation to cGMP-immunoreactivity in bovine penile smooth muscle [J]. J Chem Neuroanat, 2000, 19(2) :81-91.
  • 8Hayashida H, Okamura T, Tomoyoshi T, et al. Neurogenic nitric oxide mediates relaxation of canine corpus cavernosum [ J ]. J Urol, 1996, 155(3):1122-1127.
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中华男科学杂志
2005年 第7期

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