摘要
G_(9315)是从胀果甘草中提取的含有6个黄酮体的复合物,1mg剂量显著抑制巴豆油诱发的小鼠耳部水肿,2mg剂量明显抑制二甲基苯蒽(DMBA)合并巴豆油诱发的小鼠皮肤乳头瘤的生成,表现出较强的抗促癌作用。小鼠口服G_(9315)0.5g/kg(po×7),明显对抗环磷酰胺70mg/kg(ip×1)诱发的骨髓细胞微核增多。G_(9315)20~40μg/ml显著抑制TPA促进的32Pi参入HeLa细胞的磷脂部分。
G9315,a complex extracted from Glycyrrhizae inflata Bat(Ⅲ),consists of 6 flavonoids with significant antioxidant effects.At 1 mg dose it inhibited the mouse ear edema induced by croton oil,and showed strong anti-promoting effects on two-stage carcinogenesis in mouse skin induced by DMBA plus croton oil. The TPA enhanced 32Pi-incorporation into phospholipid fraction in HeLa cells was inhibited ,and the micronuclei in mouse bone marrow cells induced by cytoxan was also depressed.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1995年第5期349-352,共4页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金