计算机控制的避暗自动测试系统

Manufacture of Computer-based Testing and Analyzing System for Measuring Step-through Performance

计算机控制的避暗自动测试系统刘新民，陈善广，王圣平，邢志新，于澎仁，王立为，肖培根，宿双宁（中国医学科学院，中国协和医科大学，药用植物研究所，北京１０００９４）随着人类寿命的延长和老龄化社会的到来，有关促智抗衰老药物的研究已成为现代药理学的研究热点之...

Abstract The computer-Based Testing. and Analysing System for measuring Step-Through (avoiding darkness) performance (CTASS) has been developed. The system is based on the infrared beams which transfer actions of mice inside the boxes into signals of voltage. The signals are fed into the computer through A/D converter to computer for software processing. The functions which have been realized include, but not limited to: signal sampling and data curve displaying; intelligent identification and elimination of jamming signal; auto-calculation of number of errors (No) in all channels, latent period (LP) of entering into the light chamber, total time of mice staying in the light chamber (safty place T1)and dark chamber (error place Td); hardcopy of screen graphics and resulting output by various printers. The CATSS system was applied to test normal mice and the cognition-deficient mice induced by anisodine, a M-Cholinergic antagonist at a dose of 1-10 mg/kg ip. The data collected by the system were compared and proved to be consistent with those acquired by manual labour. The system has produced refined and accurate information refined to a maximum extent and guaranteed scientifically sound experimental results. It is foreseable that introducing the computer into pharmacological researches will update and advance their methodology.