奥氮平和利培酮治疗老年期精神分裂症对照研究

A controlled study of olanzapine and risperidol in the treatment of elderly patients with schizophrenia

目的比较奥氮平和利培酮对老年期精神分裂症的治疗效果。方法以奥氮平与利培酮对43例老年期精神分裂症患者进行为期8wk的对照治疗;采用阳性和阴性症状量表评定疗效,用副反应量表评定副反应。结果奥氮平组显效率72.7%,有效率90.9%;利培酮组显效率71.4%,有效率90.5%;副反应少而轻微,奥氮平主要副反应为嗜睡,利培酮主要副反应为锥体外系反应。结论两药治疗老年期精神分裂症疗效相当,且安全性较高。

Objective To compare the clinical efficacy between olanzapine and risperidol in the treatment of elderly patients with schizophrenia. Methods 43 elderly patients with schizophrenia were randomly assigned olanzapine group and risperidol group for 8 weeks. The positive and negative symptoms scale (PANSS) was used to evaluated the efficacy, while the treatment emergent symptoms scale (TESS) was used to assess the side effects. Results Findings indicated that efficacy of olanzapine was similar to that of risperidol. The response rate was 90.9% for olanzaine and 90.5% for risperidol. The main side effect of olanzapine was somnolence, with EPS for risperidol. Conclusions Both olanzapine and risperidol are effective and safe in the treatment of elderly patients with schizophrenia.