乳房深部温度测量和乳癌早诊探讨

OEEP TEMPERATURE DISTRIBUTION MEASUREMENT OF BREAST & EARLY DIAGNOSIS EXPLORATION OF BREAST CANCER

本文结合肿瘤诊断中所用常规针吸活检穿刺针，进行了乳房深部温度分布测量，设计了专用乳房深部单针多点测温探针和针吸活检穿刺加压定位器；该测温探针长１０ｃｍ，外径０．４ｍｍ，从针尖起，间隔６ｍｍ依次装有４个感温点，测温精度为±０．１℃，响应时间５秒以内；根据Ｘ线照片定位，在针吸活检过程中对５８例乳腺肿瘤患者做了病变区深部温度测量。按针吸法细胞病理学诊断结果将数据分组，初步分析表明病变部位深部温度常高于健侧对应部位及肿瘤周边的深部温度，具有较高的平均温度和较大的温差；且恶性癌变组平均温度和最大温差均高子良性病变组（有较显著统计差异Ｐ＜０．０ｌ）。作者认为乳房深部平均温度值和最大温差值结合人体体温有可能作为乳癌早期诊断的客观指标，值得进一步研究探讨。

Deep temperature distribution in breast cancer region was measured with a special thermometerduring the aspiration biopsy without additional uncomfortable feeling.This thermometer is a single multi-sensorneedle inside an aspiration biopsy needle(0.7 mm in diameter).The thermometer is 10cm in length,0.4mm indiameter and has 4 thermo-sensor points which are placed in order from the top of the needle and separated intoaspace of 6mm between each two points. The temperature sensitivity of the thermosensor is±0.1℃,and its re-sponsing time is less than 5 seconds. According to the breast X-ray image,during the aspiration biopsy,using a perforated-grid mammographiccompression device which is also designed by ourself,deep temperature of disease region of breast was measuredwith the single multi-sensor needle thermometer for 58 patients with breast tumor.Results suggested that thedeep temperature of cancer region was often higher than that of nearby area of the same breast and the normalbreast at the opposite side,Besides,the mean temperature and the maximum temperature difference of the ma-lignancy tumor patient group are often higher than that of non-malignancy disease patient group. Authors suggested that the mean temperature and the maximum temperature difference of deep region of thebreast might be a valuable index for the early breast cancer diagnosis.