摘要
探讨了离子导入和月桂氮酮预处理对吡罗昔康通过离体大鼠皮肤的影响，选用Ｖａｌｉａ－Ｃｈｉｅｎ扩散池和改良的Ｆｒａｎｚ扩散池，得到吡罗昔康饱和液及其膜剂的透皮速率分别为４．８±０．１７和１．０±０．０４μｇ／ｈ·ｃｍ－２，采用电流强度为０．８ｍＡ的离子导入，药物的透皮速率分别增加１１倍和８倍．另外，月桂氮酮预处理合用离子导入能产生协同作用，其透皮速率为单用月桂氮酮与单用电场透皮速率之和的４倍。
The influence of iontophoresis and pretreatment with laurocapram(2) on delivery of piroxicam(1) across the rat skin was investigated.Using the Valia-Chiew and modified Franz diffusion cells,the percutaneous fluxes of 1 from the saturated solution and film were 4.8±0.17 and 1.0±0.0μg/h·cm2,respectively.With iontophoresis applying electric current of 0.8 mA be the fluxes of 1 increased 11 and 8-fold. respectively. Furthermore,if 2 pretreatment was used with iontophoresis,the percutaneous flux was 4-fold as the sum of the fluxes using 2 along and using electric current alone.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1995年第2期60-62,共3页
Chinese Journal of Pharmaceuticals
基金
国家自然科学基金
浙江省卫生厅资助
