摘要
介绍了含硫多肽类抗生素诺西肽（ｎｏｓｉｈｅｐｔｉｄｅ）产生菌Ｓ．ａｃｔｕｏｓｕｓ的诱变谱系及诺西肽发酵条件的研究。经紫外照射处理及自然分离获得的诱变菌株Ｚ＿（１０），其在适当的通气条件下培养，补入１％葡萄糖和２．５‰硫酸钠，诺西肽产量可达１０００μｇ／ｍｌ左右，比野生株原始产量提高１０倍。本研究为诺西肽工业生产奠定了基础。
The results of strain improvement by UV mutation and fermentation condition optimization for the nosiheptide-producing strain. Streptomyces, actuosus sp Z_(10) are reported. It showed that when the mutant Z_(10) obatined by mutational breeding was cultured under optimal conditions (28～30℃,270r/min, addition of 10% glucose and 0.25% Na_2SO_4) for 10d, it produced 1000μg/ml of nosiheptide. It is about 10 times the parent strain.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1995年第10期438-440,458,共4页
Chinese Journal of Pharmaceuticals
关键词
诺西肽
诱变
发酵
制药
nosiheptide, mutation, fermentation
