微生物来源的胆固醇生物合成酶抑制剂研究：抗生素SIPI－8926－III的研究

INHIBITOR OF CHOLESTEROL BIOSYNTHETIC ENZYME FROM MICROORGANISMS:STUDIES ON ANTIBIOTIC SIPI-8926-111

从镰孢ＳＩＰＩ－８９２６菌株的发酵液中，经溶媒萃取、硅胶柱色谱分离和重结晶等，分离出其中一个具有抑制胆固醇生物合成活性的化合物ＳＩＰＩ－８９２６－Ⅲ。通过对其理化特性和ＵＶ、ＩＲ、ＭＳ、ＮＭＲ（１Ｈ和１３Ｑ等光谱的分析，确定其结构为Ｎ－［２－（４－羟基苯基）乙基］乙酰胺，与文献报道Ｎ－乙酰酪胺结构一致。

From the fermentation broth of Fusarium strain SIPI-8926,a inhibitor of cholesterol synthetic enzyme designated as antibiotic SIPI-8926-Ⅲ (1) was isolated by solvent extraction, silica gel chromatography and crystallization. The structure of 1 was elucidated by means of physico-chemical properties,UV,IR, MS, NMR (1H and 13C) spectra,and was identical with that of N-acetyltyramine.