摘要
以环庚三烯为原料，经氰化、环加成、水解和重排降解，全合成２－托品酮，总收率４０％。本法步骤短、操作简便、收率高。
Tropanone was totally synthesized from cycloheptatriene in five steps. 2-Cyano-2-tropene was prepared by reaction of 7-cyano-1,3,5-cycloheptatriene with 25% of methylamine solution in alcohol. By partially acidic hydrolysis, it was directly converted into 2-carbamido-2-tropene, which was degraded with a fresh prepared basic sodium hypochlorite solution via Hofmann rearrangement to give 2-tropanone. The overall yield was 40%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1995年第12期551-553,共3页
Chinese Journal of Pharmaceuticals
