ICP-MS法测定药用滑石粉酸溶物杂质成分

Impurity Determination in Acid-Solution of Medical Talc Powder by ICP-MS

为考察国内不同产区药用滑石粉酸溶物杂质组成情况,采用电感耦合等离子体质谱法(ICP-MS)分析药用滑石粉中酸溶物杂质成分的种类与含量,测定其中主要金属离子和代表性有害元素的含量.主要酸提取物成分Mg,Al,Ca,Fe的含量(wB)分别为(220～2200)×10-6,(9～65)×10-6,(260～2720)×10-6和(28～100)×10-6,As的含量为(0.2～0.5)×10-6,Pb的含量为(0.1～0.3)×10-6.滑石粉酸提取物中杂质金属离子总量小于样品量的1%,检出的As和Pb在通常使用量下,不会达到人体中毒剂量.

To determine the impurity composition,medical talc powder (MTP) is analyzed by ICP-MS for the contents of the main elements and the harmful elements in acid-solution of MTP.The contents of main elements Mg,Al,Ca,Fe are (220~2 200)×10 -6 ,(9~65)×10 -6 ,(260~2 720 )×10 -6 ,(28~100)×10 -6 and As is (0.2~0.5)×10 -6 ,Pb is (0.1~0.3)×10 -6 .The total impurity elements of the sample are less than 1%.The quantity of As,Pb at normal MTP dosage will not do harm to human body.