苦黄颗粒治疗黄疸型病毒性肝炎的临床疗效分析

Clinical curative effect and safety of Kuhuang granule in treatment of jaundice virus hepatitis

目的:观察苦黄颗粒剂治疗黄疸型病毒性肝炎的效果及安全性。方法:采用随机对照方法,试验组用苦黄颗粒6g,每天3次;对照组用苦黄注射液30ml,加入5%葡萄糖500ml,静滴,每天1次。疗程3周。结果:两组血清总胆红素治疗前后均有显著性差异(P<0.05),而两组间无显著性差异(P>0.05)。两组总胆红素复常率分别为74.72%和79.79%(P>0.05)。试验组临床痊愈率32.97%,显效率41.75%,有效率19.78%。对照组临床痊愈率40.43%,显效率39.36%,有效率10.64%。两组间痊愈和显效率比较无统计学差异。结论:苦黄颗粒和苦黄注射液在黄疸型病毒性肝炎的退黄降酶方面疗效相似,无显著性差异。

Objective To observe curative effect and safety of Kuhuang granule in treatment of jaundice virus hepatitis. Method The patients were randomly assigned into treatment group and control group. The treatment lasted for 3 weeks. Patients in treatment group were given oral taken with Kuhuang granule 6 g thrice per day, patients in control group were intravenously injected with 30 ml Kuhuang dissolved in 500 ml 5% glucose. Results There was a significant difference of serum total bilirubin between pre-treatment and post-treatment in both two groups, but there was no significant difference of serum total bilirubin between treatment group and control group. Serum total bilirubin returned to normal being 74.72% in treatment group and 79.79% in control group. There was no significant difference of clinical recovery, apparent effectiverate and effectiverate between the two groups, which were 32.97%, 41.75% and 19.78% respectively in the treatment group and 40.43%, 39.36%,10.64% in the control group. Conclusion The effect of jaundice regression and transaminase depression of Kuhuang granule and Kuhuang injection are similar in treatment of jaundice virus hepatitis.