凝血酶原时间测定在乙型病毒性肝炎患者中的临床应用

The clinical application of prothrombin time detection for patients with hepatitis B

目的 了解凝血酶原时间(PT)、国际标准化比值(INR)及凝血酶原活动度(PTA) 3项指标在乙型病毒性肝炎(乙肝)各型患者中的分布情况,及血清丙氨酸转氨酶(ALT)对乙肝患者诊断和治疗的指导作用。方法 对某院5 33例乙肝患者及4 0例健康对照者(对照组) ,采用ACL 2 0 0型凝血仪及配套试剂测定PT ,INR及PTA值,采用贝克曼CX 9生化仪及配套试剂测定ALT值;数据以平均数和标准差进行方差分析和q检验。结果 PT ,INR ,PTA及ALT在对照组和各型乙肝患者组经方差分析,差异有统计学意义(P <0 .0 1) ;在各型乙肝患者组经q检验,两两比较分析其组间差异性,PTA ,INR及ALT比PT更多见。结论 PT ,INR ,PTA及ALT 4项指标可以反映乙肝患者病情的严重程度,也可作为其病程变化和预后的指标。

Objective To assess the distribution of prothrombin time (PT), international normalized ratio (INR) and prothrombin activity (PTA) markers among patients with hepatitis B, and to evaluate the importance of detection of alanine transaminase (ALT) for the diagnosis and treatment of hepatitis B. Methods Five hundred and thirty-three hepatitis B patients and 40 healthy persons were chosen as study subjects. PT, INR and PTA values were detected by ACL-200 coagulometer and reagents, seral ALT values were detected by CX-9 biochemical apparatus, data were analyzed with ANOVA and q test. Results There were significant differences in PT, INR, PTA and ALT among healthy persons and hepatitis B patients by ANOVA. Conclusion PT, INR, PTA and ALT can reflect the severity of hepatitis B and can also be as markers of the process and prognosis of disease.