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盐酸异丙嗪栓的研制及其家兔体内生物药剂学评价 被引量:1

Study and preparation of promethazine hydrochloride suppository and its biopharmacy evaluation in rabbits
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摘要 本文报告了盐酸异丙嗪栓剂的研制及其与片剂在家兔体内生物利用度的比较。试验采用双波长分光光度法测定盐酸异丙嗪的血药浓度。结果表明栓剂比片剂的达峰时间快,Tp之间有非常显著性差异(P<0.01),Cp和AUC没有显著性差异(P>0.05),栓剂的相对生物利用度为98.07%。 The promethazine hydrochloride suppository was prepared and its bioavailability in rabbits was compared with tablets. Intest,dual wavelength UV spectrophotometry was used for determing plasma concentration of promethazine hydrochloride. Theresult showed that the Tp of suppositories was quicker than that of tablets. It was shown that the difference of Tp between thetwo dosage forms was very significant(P<0. 01),while the difference of Cp and AUC between the two dosage forms was notsignificant(P>0.05).The relative bioavailability of suppositories was 98.07%。
出处 《中国医院药学杂志》 CAS CSCD 北大核心 1995年第2期66-68,共3页 Chinese Journal of Hospital Pharmacy
关键词 盐酸异丙嗪 栓剂 生物药剂学 制备 promethazine hydrochloride,suppository, biopharmacy
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